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WAS Antibody (OAAN00150)

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Gene Symbol:
WAS
Official Gene Full Name:
Wiskott-Aldrich syndrome
NCBI Gene Id:
7454
Protein Name:
Wiskott-Aldrich syndrome protein
Swissprot Id:
P42768
Protein Accession #:
NP_000368.1
Nucleotide Accession #:
NM_000377.2
Alias Symbols:
WAS, IMD2, THC, THC1, WASP, THC, IMD2, SCNX, THC1, WASP, WASPA, Wiskott-Aldrich syndrome, Wiskott-Aldrich syndrome protein, WAS
Description of Target:
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
Molecular Weight:
53 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity purified against immunogen
Application:
WB, IHC, IF
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express WAS.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express WAS.
Immunogen:
Recombinant protein of human WAS
Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid
Reconstitution and Storage:
Store at -20C. Avoid repeated freeze/thaw cycles.
Datasheets/Manuals:
Printable datasheet for anti-WAS (OAAN00150)
Preservative:
0.02% Sodium Azide
Conjugation:
Unconjugated
Isotype:
IgG
Application Info:
WB: 1:500 - 1:2,000. IHC: 1:50 - 1:200. IF: 1:10 - 1:100
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

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