Catalog No: OOMC00085
Price: $0.00
SKU
OOMC00085
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Datasheets/Manuals | Printable datasheet for OOMC00085 |
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Product Format | Powder |
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Additional Information | CAS: 755038-65-4 Molecular Formula: C34H50N8O3 |
:: | Chemical Name: N-[4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-4-[[(7R)-7-ethyl-5-methyl-6-oxo-8-propan-2-yl-7H-pteridin-2-yl]amino]-3-methoxybenzamide |
:: | Primary Activity: Kinase inhibitor: Polo-like Kinase 1 |
:: | COVID-19 Rationale: Also inhibits BRD4; SARS-CoV-2 transmembrane protein E binds to the bromodomain-containing proteins BRD2 and BRD4 |
Reconstitution and Storage | Soluble in DMSO (up to at least 25 mg/ml). Store at -20C. |
Purity | > 98% |
Reference | 1) Rudolph et al. (2009) BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity; Clin. Cancer Res. 15 3094 2) Rudolph et al. (2015) Efficacy and Mechanism of Action of Volasertib, a Potent and Selective Inhibitor of Polo-Like Kinases, in Preclinical Models of Acute Myeloid Leukemia; J. Pharmacol. Exp. Ther. 352 579 3) Ciceri et al. (2014) Dual kinase-bromodomain inhibitors for rationally designed polypharmacology; Nat. Chem. Biol. 10 305 |
Alias Symbols | BI 6727 |
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Molecular Weight | 618.82 g/mol |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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