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Catalog No: OOMC00085
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OOMC00085
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Volasertib (OOMC00085)

Datasheets/ManualsPrintable datasheet for OOMC00085
Product Info
Product FormatPowder
Additional InformationCAS: 755038-65-4
Molecular Formula: C34H50N8O3
::Chemical Name: N-[4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-4-[[(7R)-7-ethyl-5-methyl-6-oxo-8-propan-2-yl-7H-pteridin-2-yl]amino]-3-methoxybenzamide
::Primary Activity: Kinase inhibitor: Polo-like Kinase 1
::COVID-19 Rationale: Also inhibits BRD4; SARS-CoV-2 transmembrane protein E binds to the bromodomain-containing proteins BRD2 and BRD4
Reconstitution and StorageSoluble in DMSO (up to at least 25 mg/ml). Store at -20C.
Purity> 98%
Reference1) Rudolph et al. (2009) BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity; Clin. Cancer Res. 15 3094 2) Rudolph et al. (2015) Efficacy and Mechanism of Action of Volasertib, a Potent and Selective Inhibitor of Polo-Like Kinases, in Preclinical Models of Acute Myeloid Leukemia; J. Pharmacol. Exp. Ther. 352 579 3) Ciceri et al. (2014) Dual kinase-bromodomain inhibitors for rationally designed polypharmacology; Nat. Chem. Biol. 10 305
Alias SymbolsBI 6727
Molecular Weight618.82 g/mol
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