VKORC1 Antibody - N-terminal region (ARP63330_P050)

Catalog No: ARP63330_P050

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WB Suggested Anti-VKORC1 Antibody
Titration: 1.0 ug/ml
Positive Control: Fetal Brain

Rabbit Anti-VKORC1 Antibody
Catalog Number: ARP63330_P050
Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue
Observed Staining: Cytoplasmic
Primary Antibody Concentration: 1:100
Other Working Concentrations: N/A
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of VKORC1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 86%
• Peptide Sequence: Synthetic peptide located within the following region: LHVKAARARDRDYRALCDVGTAISCSRVFSSRLPADTLGLCPDAAELPGV
• Concentration: 0.5 mg/ml
• Blocking Peptide: Available upon request
• Subunit: 1

Target Info

• Gene Symbol: VKORC1
• Alias Symbols: VKOR, MST134, MST576, VKCFD2, EDTP308
• NCBI Gene Id: 79001
• Protein Name: Vitamin K epoxide reductase complex subunit 1
• Description of Target: Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.
• Uniprot ID: Q9BQB6
• Protein Accession #: NP_996560
• Nucleotide Accession #: NM_206824
• Protein Size (# AA): 92
• Molecular Weight: 10kDa
• Protein Interactions: UBC; ILK; ZMYM6NB; TMEM242; SNORA12; TMEM256; ZCCHC24; METTL7B; SPTSSA; VKORC1L1; CCDC167; CCDC12; TMEM45B; KCNK17; JAGN1; SERP1; PPA2; TRAM1; TREX1; YIF1A; EBP; ARL6IP5; PROCR; IFITM3; ATP6AP2; BCAP31; PDIA6; HDAC6; HOMER2; VAPB; CLDN10; DPM2; REEP5; TF;