Size:100 ul
Special Price $229.00 Regular Price $289.00
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ARP49558_P050
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Conjugation Options

ARP49558_P050-FITC Conjugated

ARP49558_P050-HRP Conjugated

ARP49558_P050-Biotin Conjugated

VISA Antibody - N-terminal region (ARP49558_P050)

Rating:
80% of 100
Catalog#: ARP49558_P050
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species Reactivity Human
Predicted Species Reactivity Cow, Human, Mouse
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application IHC, WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-365333 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human VISA
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Cow: 79%; Human: 100%; Mouse: 79%
Complete computational species homology data Anti-VISA (ARP49558_P050)
Peptide Sequence Synthetic peptide located within the following region: ETQAPESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGH
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-MAVS (ARP49558_P050) antibody is Catalog # AAP49558 (Previous Catalog # AAPS22409)
Datasheets/Manuals Printable datasheet for anti-MAVS (ARP49558_P050) antibody
Sample Type Confirmation

MAVS is supported by BioGPS gene expression data to be expressed in HEK293T

Target Reference Lad,S.P., (2008) Mol. Immunol. 45 (8), 2277-2287
Gene Symbol MAVS
Official Gene Full Name Mitochondrial antiviral signaling protein
Alias Symbols CARDIF, DKFZp666M015, FLJ27482, FLJ41962, IPS-1, KIAA1271, MAVS, IPS1, VISA
NCBI Gene Id 57506
Protein Name Mitochondrial antiviral-signaling protein
Description of Target Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI (ROBO3). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB), which activate NFKB, or TBK1 and IKKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound VISA. Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Swissprot Id Q2HWT5
Protein Accession # NP_065797
Nucleotide Accession # NM_020746
Protein Size (# AA) 896
Molecular Weight 56kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express VISA.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express VISA.
Protein Interactions MIB2; KCNIP3; DDX58; UBC; TRAF6; TRAF3; UBXN1; TMEM173; SMURF2; HCVgp1; AMFR; MFN1; MFN2; MUL1; TOMM70A; FLOT2; NDFIP1; SMURF1; TBK1; IKBKG; TICAM1; TRAF2; MAP3K7; SRC; IRF7; IRF3; IKBKE; TSPAN6; RARRES3; ECSIT; PCBP2; ITCH; IFIH1; PSMA7; WDR5; HECTD3; PD
  1. What is the species homology for "VISA Antibody - N-terminal region (ARP49558_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Cow, Human, Mouse".

  2. How long will it take to receive "VISA Antibody - N-terminal region (ARP49558_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "VISA Antibody - N-terminal region (ARP49558_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "VISA Antibody - N-terminal region (ARP49558_P050)"?

    This target may also be called "CARDIF, DKFZp666M015, FLJ27482, FLJ41962, IPS-1, KIAA1271, MAVS, IPS1, VISA" in publications.

  5. What is the shipping cost for "VISA Antibody - N-terminal region (ARP49558_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "VISA Antibody - N-terminal region (ARP49558_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "VISA Antibody - N-terminal region (ARP49558_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "56kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "VISA Antibody - N-terminal region (ARP49558_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "MAVS"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "MAVS"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "MAVS"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "MAVS"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "MAVS"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "MAVS"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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