VDU1 Antibody - C-terminal region (OAAB15791)

Catalog No: OAAB15791

Size:400ul

Western blot analysis of anti-VDU1 Pab (Cat. # OAAB15791) in T47D cell line lysate (35ug/lane). VDU1(arrow) was detected using the purified Pab.

Product Info

• Predicted Species Reactivity: Human, Cow
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
• Additional Information: Precautions: VDU1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta- arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains
  Cellular Location: Cytoplasm, perinuclear region. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear
  Tissue Location: Widely expressed.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This VDU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 799-829 amino acids from the C-terminal region of human VDU1.
• Predicted Homology Based on Immunogen Sequence: Cow; Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:1000

Target Info

• Gene Symbol: USP33
• Alias Symbols: VDU1
• NCBI Gene Id: 23032
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 33
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: Q8TEY7
• Protein Accession #: NP_055832.3
• Molecular Weight: 106727 Da