VDAC1 Recombinant Protein (OPCD07877)

Catalog No: OPCD07877

VDAC1 Recombinant Protein (OPCD07877) using SDS-PAGE

VDAC1 Recombinant Protein (OPCD07877) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Subcellular Location: Membrane, Mitochondrion
  Predicted Isoelectric Point: 8.6
  Residues: Ala2-Ala283
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: VDAC1
• Gene Full Name: voltage dependent anion channel 1
• Alias Symbols: outer mitochondrial membrane protein porin 1;plasmalemmal porin;PORIN;porin 31HL;porin 31HM;sperm binding protein 1a;VDAC-1;voltage-dependent anion-selective channel protein 1.
• NCBI Gene Id: 7416
• Protein Name: Voltage-dependent anion-selective channel protein 1
• Description of Target: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).
• Uniprot ID: P21796
• Protein Accession #: NP_003365.1
• Nucleotide Accession #: NM_003374.2
• Protein Size (# AA): Ala2~Ala283
• Molecular Weight: 61kDa