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VDAC1 Antibody (OASE00304)

100ug
$379.00
In Stock
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Conjugation Options

OASE00304-FITC Conjugated

OASE00304-HRP Conjugated

OASE00304-Biotin Conjugated

Predicted Species Reactivity:
Human, mouse, rat
Clonality:
Monoclonal
Clone:
S152B-23
Isotype:
IgG2a
Host:
Mouse
Application:
WB, ICC, IHC
Additional Information:
Background Info: Detects a 30 kDa protein. Does not cross-react with VDAC2 or VDAC3 (based on KO validation results)
:::
Scientific Background: Voltage-dependent anion-selective channel protein 1 (also known as VDAC, VDAC1 or outer mitochondrial membrane protein porin 1) is the the outer mitochondrial membrane receptor for hexokinase and BCL2L1. VDAC forms a channel through the mitochondrial membrane and is involved in small molecule diffusion, cell volume regulation and apoptosis. VDAC may participate in the formation of the permeability transition pore complex (PTPC), which is responsible for the release of mitochondrial products that triggers apoptosis.
:::
Certificate of Analysis: 1ug/mL was sufficient for detection of VDAC1 in 20 ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Reconstitution and Storage:
Store at -20C. Shipping in Blue Ice or 4C.
Gene Symbol:
VDAC1
NCBI Gene Id:
7416
Official Gene Full Name:
voltage-dependent anion channel 1
Swissprot Id:
P21796
Protein Accession #:
NP_003365.1.
Replacement Item:
This antibody may replace item sc-171785 from Santa Cruz Biotechnology.
Purification:
Protein G Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express VDAC1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express VDAC1.
Immunogen:
Fusion protein amino acids 1-
283 (full-length) of human VDAC1 (Accession no. P21796)
Mouse: 98% identity (279/283 amino acids identical)
Rat: 98% identity (279/283 amino acids identical)
>60% identity with VDAC2 and VDAC3
Concentration:
1mg/mL
Datasheets/Manuals:
Printable datasheet for OASE00304
Dilution:
1:1000 WB
Storage Buffer:
PBS pH 7.4, 50% glycerol, 0.1% sodium azide

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