VAV1 Antibody (Phospho-Tyr174) (OASG07504)

Catalog No: OASG07504

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human Vav1 around the phosphorylation site of Y174. Location: 110-190aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Tyr174
• Specificity: Phospho-Vav1 (Tyr174) Polyclonal Antibody detects endogenous levels of Vav1 protein only when phosphorylated at Y174.
• Application Info: WB 1:500-1:2000; ELISA 1:10000;

Target Info

• Gene Symbol: VAV1
• Gene Full Name: vav 1 guanine nucleotide exchange factor
• Alias Symbols: VAV
• NCBI Gene Id: 7409; 22324;
• Description of Target: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Uniprot ID: P15498, P27870, P54100
• Molecular Weight: 98 kDa