VASP Antibody (Phospho-Thr278) (OASG07488)

Catalog No: OASG07488

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human VASP around the phosphorylation site of T278. Location: 220-300aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Thr278
• Specificity: Phospho-VASP (T278) Polyclonal Antibody detects endogenous levels of VASP protein only when phosphorylated at T278.
• Application Info: IHC 1:100-1:300; ELISA 1:40000;

Target Info

• Gene Symbol: VASP
• Gene Full Name: vasodilator-stimulated phosphoprotein
• Alias Symbols: VASP, Vasodilator-stimulated phosphoprotein, VASP
• NCBI Gene Id: 7408; 22323;
• Description of Target: Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
• Uniprot ID: P50552, P70460
• Molecular Weight: 46/50 kDa