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Catalog No: OAAF04404 (Formerly GWB-ASF060)
Size:100 ug
Price: $344.00
SKU
OAAF04404
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for USP13 Antibody (OAAF04404)
Product Info
Predicted Species ReactivityHuman|Mouse
Product FormatLiquid
ClonalityPolyclonal
HostRabbit
ApplicationEnzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Reconstitution and Storage-20°C
ImmunogenThe antiserum was produced against synthesized peptide derived from human USP13.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
SpecificityUSP13 antibody detects endogenous levels of total USP13 protein.
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
DilutionThe optimal working dilution should be determined by the end user.
ReferenceTimms K.M., Gene 217:101-106(1998).
Mural R.J., Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Dephoure N., Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Gene SymbolUSP13
Gene Full Nameubiquitin specific peptidase 13
Alias Symbolsdeubiquitinating enzyme 13;Isopeptidase T-3;IsoT-3;ISOT3;ubiquitin carboxyl-terminal hydrolase 13;ubiquitin specific peptidase 13 (isopeptidase T-3);ubiquitin specific protease 13 (isopeptidase T-3);ubiquitin thioesterase 13;ubiquitin thiolesterase 13;ubiquitin-specific-processing protease 13.
NCBI Gene Id8975
Protein NameUbiquitin carboxyl-terminal hydrolase 13
Description of TargetDeubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
Uniprot IDQ92995
Protein Accession #NP_003931.2
Molecular Weight97 kDa
  1. What is the species homology for "USP13 Antibody (OAAF04404)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse".

  2. How long will it take to receive "USP13 Antibody (OAAF04404)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "USP13 Antibody (OAAF04404)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "USP13 Antibody (OAAF04404)"?

    This target may also be called "deubiquitinating enzyme 13;Isopeptidase T-3;IsoT-3;ISOT3;ubiquitin carboxyl-terminal hydrolase 13;ubiquitin specific peptidase 13 (isopeptidase T-3);ubiquitin specific protease 13 (isopeptidase T-3);ubiquitin thioesterase 13;ubiquitin thiolesterase 13;ubiquitin-specific-processing protease 13." in publications.

  5. What is the shipping cost for "USP13 Antibody (OAAF04404)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "USP13 Antibody (OAAF04404)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "USP13 Antibody (OAAF04404)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "97 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "USP13 Antibody (OAAF04404)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "USP13"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "USP13"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "USP13"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "USP13"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "USP13"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "USP13"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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