UROS Protein (OOPA00149)

Catalog No: OOPA00149

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Sterile filtered colorless solution.
• Host: Escherichia Coli.
  Product Introduction: Uroporphyrinogen III synthase (UROS) is an enzyme involved in the 4th step of porphyrin metabolism and in the conversion of hydroxymethyl bilane into uroporphyrinogen III. Defects in the UROS protein can cause molecular lesions which lead to the autosomal recessive Gunther disease, otherwise known as congenital erythropoietic porphyria (CEP).
  Product Description: UROS produced in E.Coli is a single, non-glycosylated polypeptide chain containing 285 amino acids (1-265 a.a.) and having a molecular mass of 30.7kDa. UROS is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
• Reconstitution and Storage: UROS Human Recombinant although stable at 4C for 1 week, should be stored below -18C. Please prevent freeze thaw cycles.
• Formulation: UROS protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl.
• Purification: Greater than 95.0% as determined by SDS-PAGE.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Peptide Sequence: MGSSHHHHHH SSGLVPRGSH MKVLLLKDAK EDDCGQDPYI RELGLYGLEA TLIPVLSFEF LSLPSFSEKL SHPEDYGGLI FTSPRAVEAA ELCLEQNNKT EVWERSLKEK WNAKSVYVVG NATASLVSKI GLDTEGETCG NAEKLAEYIC SRESSALPLL FPCGNLKREI LPKALKDKGI AMESITVYQT VAHPGIQGNL NSYYSQQGVP ASITFFSPSG LTYSLKHIQE LSGDNIDQIK FAAIGPTTAR ALAAQGLPVS CTAESPTPQA LATGIRKALQ PHGCC.

Target Info

• Gene Symbol: UROS
• Alias Symbols: Uroporphyrinogen-III synthase, UROIIIS, UROS, Hydroxymethylbilane hydrolyase [cyclizing], Uroporphyrinogen-III cosynthase.
• Protein Size (# AA): Recombinant