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Catalog No: ARP36350_P050
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ARP36350_P050
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Datasheets/ManualsPrintable datasheet for anti-UPF1 (ARP36350_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB, IHC
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human UPF1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 79%; Horse: 93%; Human: 100%; Mouse: 93%; Rat: 93%; Zebrafish: 83%
Peptide SequenceSynthetic peptide located within the following region: RGTPKGKTGRGGRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQG
Concentration0.5 mg/ml
Blocking PeptideFor anti-UPF1 (ARP36350_P050) antibody is Catalog # AAP36350 (Previous Catalog # AAPP08657)
ReferenceAjamian,L., (2008) RNA 14 (5), 914-927
Gene SymbolUPF1
Gene Full NameUPF1 regulator of nonsense transcripts homolog (yeast)
Alias SymbolsUTF, HUPF1, NORF1, RENT1, smg-2, pNORF1
NCBI Gene Id5976
Protein NameRegulator of nonsense transcripts 1
Description of TargetUPF1 is a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. UPF1 is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Uniprot IDQ92900
Protein Accession #NP_002902
Nucleotide Accession #NM_002911
Protein Size (# AA)1118
Molecular Weight123kDa
Protein InteractionsUBC; SUMO2; STAU1; CDC37; IVNS1ABP; MOV10; DNA2; POP1; LIN28A; UPF3B; STAU2; UPF2; EZH2; BMI1; SUZ12; RNF2; GNPTG; RHOXF2; ACSS2; NADSYN1; PLEKHB2; PLEKHA5; TARDBP; RPRD2; ABHD16A; NDUFB10; DXO; SMG1; RUVBL2; RBM8A; SMG7; EIF4A3; RUVBL1; GSPT2; SMG5; GSPT
  1. What is the species homology for "UPF1 Antibody - middle region (ARP36350_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish".

  2. How long will it take to receive "UPF1 Antibody - middle region (ARP36350_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "UPF1 Antibody - middle region (ARP36350_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "UPF1 Antibody - middle region (ARP36350_P050)"?

    This target may also be called "UTF, HUPF1, NORF1, RENT1, smg-2, pNORF1" in publications.

  5. What is the shipping cost for "UPF1 Antibody - middle region (ARP36350_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "UPF1 Antibody - middle region (ARP36350_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "UPF1 Antibody - middle region (ARP36350_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "123kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "UPF1 Antibody - middle region (ARP36350_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "UPF1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "UPF1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "UPF1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "UPF1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "UPF1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "UPF1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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