UHRF1 Antibody (OABF01689)

Catalog No: OABF01689

Size:100UL

Formalin-fixed and paraffin embedded mouse lung labeled with Anti-UHRF1 Polyclonal Antibody, Unconjugated (OABF01689) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Formalin-fixed and paraffin embedded rat testis labeled with Anti-UHRF1 Polyclonal Antibody, Unconjugated (OABF01689) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Product Info

• Predicted Species Reactivity: Chicken|Dog|Guinea Pig|Horse|Human|Mouse|Porcine|Rat
• Product Format: Liquid Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin
• Additional Information: Subcellular location: Helical
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human UHRF1
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:300-1,000
  IHC-P: 1:200-400
  Fluorescent (IHC-P): 1:50-200
  Optimal dilutions should be determined by the end user.

Target Info

• Gene Symbol: UHRF1|UHRF2
• Gene Full Name: ubiquitin like with PHD and ring finger domains 1|ubiquitin like with PHD and ring finger domains 2
• Alias Symbols: E3 ubiquitin-protein ligase UHRF1;E3 ubiquitin-protein ligase UHRF2;hNP95;hUHRF1;huNp95;ICBP90;inverted CCAAT box-binding protein of 90 kDa;NIRF;Np95;np95/ICBP90-like RING finger protein;Np95-like ring finger protein;nuclear phosphoprotein 95;nuclear protein 95;nuclear protein 97;nuclear zinc finger protein Np95;nuclear zinc finger protein NP97;RING finger protein 106;RING finger protein 107;RING-type E3 ubiquitin transferase UHRF1;RING-type E3 ubiquitin transferase UHRF2;RNF106;RNF107;TDRD22;TDRD23;transcription factor ICBP90;ubiquitin-like PHD and RING finger domain-containing protein 1;ubiquitin-like PHD and RING finger domain-containing protein 2;ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase;ubiquitin-like, containing PHD and RING finger domains, 2;ubiquitin-like-containing PHD and RING finger domains protein 2;URF2.
• NCBI Gene Id: 115426|29128
• Description of Target: Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.Tissue specificity:Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer. UHRF2 is an E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.