- Toll Free: 888-880-0001
- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
| Datasheets/Manuals | Printable datasheet for UCP1 Antibody (OACA07334) (OACA07334) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Conjugation | Unconjugated |
| Application | Enzyme-linked immunosorbent assay|Immunohistochemistry |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | Recombinant Human Mitochondrial brown fat uncoupling protein 1 protein (1-307AA) |
| Purification | Affinity Purified |
| Preservative | 0.02% sodium azide |
| Formulation | PBS with, 50% glycerol, pH7.3. |
| Reference | [1]"Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio."Herrmann S.M., Wang J.G., Staessen J.A., Kertmen E., Schmidt-Petersen K., Zidek W., Paul M., Brand E.J. Mol. Med. 81:327-332(2002). [2]"A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus."Mori H., Okazawa H., Iwamoto K., Maeda E., Hashiramoto M., Kasuga M.Diabetologia 44:373-376(2000). [3]"Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe."Bouillaud F., Villarroya F., Hentz E., Raimbault S., Cassard A.M., Ricquier D.Clin. Sci. 75:21-27(1987). |
| Gene Symbol | UCP1 |
|---|---|
| Gene Full Name | uncoupling protein 1 |
| Alias Symbols | mitochondrial brown fat uncoupling protein 1;SLC25A7;solute carrier family 25 member 7;thermogenin;UCP;uncoupling protein 1 (mitochondrial, proton carrier). |
| NCBI Gene Id | 7350 |
| Protein Name | Mitochondrial brown fat uncoupling protein 1 |
| Description of Target | Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity). |
| Uniprot ID | P25874 |
| Protein Accession # | NP_068605 |
| Nucleotide Accession # | NM_021833 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
See our General FAQ page.
-
What is the species homology for "UCP1 Antibody (OACA07334)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
-
How long will it take to receive "UCP1 Antibody (OACA07334)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
-
What buffer format is "UCP1 Antibody (OACA07334)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "UCP1 Antibody (OACA07334)"?
This target may also be called "mitochondrial brown fat uncoupling protein 1;SLC25A7;solute carrier family 25 member 7;thermogenin;UCP;uncoupling protein 1 (mitochondrial, proton carrier)." in publications.
-
What is the shipping cost for "UCP1 Antibody (OACA07334)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
-
What is the guarantee for "UCP1 Antibody (OACA07334)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
-
Can I get bulk pricing for "UCP1 Antibody (OACA07334)"?
You can get bulk pricing for this item by going here.
-
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "UCP1 Antibody (OACA07334)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
-
What are positive controls for "UCP1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What are negative controls for "UCP1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What other proteins interact with "UCP1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
-
What biological processes are associated with "UCP1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
-
What cellular components are associated with "UCP1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
-
What protein functions are associated with "UCP1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
