UCHL1 Antibody (OAAB22236)

Catalog No: OAAB22236

Size:100ul

Western blot detection of PGP9. 5 Antibody (OAAB22236) in U251, Raji and IMR32 cell lysates and using PGP9. 5 Antibody (OAAB22236) (1:1000 diluted). Predicted band size: 25KDa. Observed band size: 25KDa.

Immunocytochemistry stain of COS7 using PGP9. 5 Antibody (OAAB22236) (1:300).

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid
• Clonality: Monoclonal
• Host: Rabbit
• Application: WB, ICC
• Additional Information: Function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Predicted Homology Based on Immunogen Sequence: Human, Mouse
• Preservative: 0.02% Sodium Azide, 0.1% BSA, and 50% glycerol
• Formulation: Purified mouse monoclonal in PBS (pH 7.4) containing with 0.2% sodium azide, 50% glycerol, 0.1%BSA
• Application Info: WB: 1:1000
  ICC: 1:300
• Reference: Hillier L.W.,et al.Nature 434:724-731(2005).
  Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
  Day I.N.M.,et al.Biochem. J. 268:521-524(1990).
  Choi J.,et al.J. Biol. Chem. 279:13256-13264(2004).
  Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.
  

Target Info

• Gene Symbol: UCHL1
• Gene Full Name: ubiquitin C-terminal hydrolase L1
• Alias Symbols: NDGOA, PARK5, PGP95, SPG79, PGP9.5, Uch-L1, HEL-117, PGP 9.5, HEL-S-53
• NCBI Gene Id: 7345
• Description of Target: The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.
• Uniprot ID: P09936
• Protein Accession #: NP_004172.2
• Nucleotide Accession #: NM_004181.4
• Molecular Weight: 25 kDa