UBQLN4 Antibody (OAAF04402)

Catalog No: OAAF04402 (Formerly GWB-ASF059)

Size:100 ug

Western blot analysis of extracts from mouse brain cells, using UBQLN4 Antibody. The lane on the right is treated with the synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using UBQLN4 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human UBQLN4.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: UBQLN4 antibody detects endogenous levels of total UBQLN4 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1:500~1:3000; IHC: 1:50~1:100; ELISA: 1:40000
• Reference: Davidson J.D., Hum. Mol. Genet. 9:2305-2312(2000).
  Ota T., Nat. Genet. 36:40-45(2004).
  Gregory S.G., Nature 441:315-321(2006).

Target Info

• Gene Symbol: UBQLN4
• Gene Full Name: ubiquilin 4
• Alias Symbols: A1U;A1Up;ataxin-1 interacting ubiquitin-like protein;ataxin-1 ubiquitin-like interacting protein;ataxin-1 ubiquitin-like-interacting protein A1U;C1orf6;CIP75;connexin43-interacting protein of 75 kDa;UBIN;ubiquilin-4.
• NCBI Gene Id: 56893
• Protein Name: Ubiquilin-4
• Description of Target: Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205).
• Uniprot ID: Q9NRR5
• Protein Accession #: NP_064516.2
• Molecular Weight: 63 kDa