UBE1L Antibody (OAAD00373)

Catalog No: OAAD00373

Size:0.1ml

western blot analysis using UBE1L mouse mAb against Raji (1) and THP-1 (2) cell lysate.

Product Info

• Predicted Species Reactivity: Human
• Clonality: Monoclonal
• Clone: 5B10
• Isotype: IgG1
• Host: Mouse
• Application: WB
• Reconstitution and Storage: Store at 4C, for long term storage, store at -20C.
• Immunogen: Purified recombinant fragment of human UBE1L expressed in E. Coli.
• Formulation: Ascitic fluid containing 0.03% sodium azide.
• Application Info: Western Bloting: 1/500 - 1/2000.
  ELISA: Propose dilution 1/10000.
  Not yet tested in other applications.
  Determining optimal working dilutions by titration test.
• Reference: 1. Cancer Res. 1992 Mar 15;52(6):1536-41 2. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6071-5.
  3. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3806-11.

Target Info

• Alias Symbols: D8, UBE2, UBA1B, UBE1L
• NCBI Gene Id: 7318
• Description of Target: The modification of proteins with ubiquitin is an important cellular mechanism for targeting.Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family.
  The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
• Uniprot ID: P41226
• Molecular Weight: 112kDa