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Datasheets/Manuals | Printable datasheet for TYRO3 Antibody (OAAB07217) |
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Predicted Species Reactivity | Human |
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Product Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Clonality | Monoclonal |
Clone | 64CT15.6.2.3.1 |
Host | Mouse |
Application | Immunofluorescence, Immunohistochemistry-Paraffin |
Additional Information | Precautions: TYRO3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
:: | Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 |
:: | Cellular Location: Cell membrane; Single-pass type I membrane protein Tissue Location: Abundant in the brain and lower levels in other tissues |
Reconstitution and Storage | Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | This TYRO3 Monoclonal antibody is generated from mouse immunized with human recombinant TYRO3 protein. |
Predicted Homology Based on Immunogen Sequence | Human |
Concentration | Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Application Info | IHC-P: 1:50~100 IF: 1:10~50 |
Gene Symbol | TYRO3 |
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Gene Full Name | TYRO3 protein tyrosine kinase |
Alias Symbols | BYK;Dtk;Etk-2;Rek;RSE;Sky;Tif;tyrosine-protein kinase byk;tyrosine-protein kinase DTK;tyrosine-protein kinase receptor TYRO3;tyrosine-protein kinase RSE;tyrosine-protein kinase SKY;tyrosine-protein kinase TIF. |
NCBI Gene Id | 7301 |
Protein Name | NP_006284, NP_006284.2, Q06418 |
Description of Target | Tyrosine-protein kinase receptor TYRO3, tyrosine-protein kinase receptor TYRO3 isoform 1 precursor [Homo sapiens] |
Uniprot ID | https://www.uniprot.org/uniprot/Q06418 |
Protein Accession # | https://www.ncbi.nlm.nih.gov/protein/NP_006284,NP_006284.2 |
Molecular Weight | 96905 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "TYRO3 Antibody (OAAB07217)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "TYRO3 Antibody (OAAB07217)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks ".
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What buffer format is "TYRO3 Antibody (OAAB07217)" provided in?
This item is provided in "Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "TYRO3 Antibody (OAAB07217)"?
This target may also be called "BYK;Dtk;Etk-2;Rek;RSE;Sky;Tif;tyrosine-protein kinase byk;tyrosine-protein kinase DTK;tyrosine-protein kinase receptor TYRO3;tyrosine-protein kinase RSE;tyrosine-protein kinase SKY;tyrosine-protein kinase TIF." in publications.
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What is the shipping cost for "TYRO3 Antibody (OAAB07217)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "TYRO3 Antibody (OAAB07217)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "TYRO3 Antibody (OAAB07217)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "96905".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "TYRO3 Antibody (OAAB07217)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "TYRO3"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "TYRO3"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "TYRO3"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "TYRO3"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "TYRO3"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "TYRO3"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.