Catalog No: OPPA01770 (Formerly GWB-C37DAC)
Size:5UG
Price: $75.00
SKU
OPPA01770
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TXN2 Protein (OPPA01770)

Datasheets/ManualsPrintable datasheet for OPPA01770
Product Info
Predicted Species ReactivityHuman
Product FormatTXN2 protein solution contains 1x PBS pH-7.4. Physical appearance: Sterile Filtered colorless solution.
HostE. Coli
::Biological Activity: Specific activity is 3-4 A650/min/mg, obtained by measuring the increase of insulin precipitation in absorbance at 650 nm resulting from the reduction of insulin.
::Product Introduction: Thioredoxin-2 is a low molecular weight redox protein. TRX2 contains a redox active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The TXN2 is involved in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. Upon stimulation of Fas, TXN2 mediates denitrosylation of mitochondria-associated caspase-3, a process required for caspase-3 activation, and promoted apoptosis. TRX2 is important at low oxidative stress conditions. MTRX is involved in the regulation of the mitochondrial membrane potential and cell death. Mitochondrial thioredoxin plays an important roles in protection against oxidant-induced apoptosis. Thioredoxin1 and thioredoxin2 have opposed regulatory functions on hypoxia-inducible factor-1alpha.
Product Description: MTRX Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 108 amino acids and having a molecular mass of 11 kDa.
Reconstitution and StorageTRX2 although stable 4C for 4 weeks, should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
PurityGreater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Peptide SequenceMTTFNIQDGP DFQDRVVNSE TPVVVDFHAQ WCGPCKILGP RLEKMVAKQH GKVVMAKVDI DDHTDLAIEY EVSAVPTVLA MKNGDVVDKF VGIKDEDQLE AFLKKLIG.
Gene SymbolTXN2
Alias SymbolsTXN, MTRX, TRX2, MT-TRX, COXPD29
NCBI Gene Id25828
Protein NameThioredoxin, mitochondrial
Description of TargetRecombinant Human Thioredoxin-2
Uniprot IDQ99757
Protein Accession #NP_036605.2
Protein Size (# AA)Recombinant
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