TXN1 Protein (OPPA02378)

Catalog No: OPPA02378

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: TXN1 solution containing 1x PBS pH 7.4. Physical appearance: Sterile filtered colorless solution.
• Host: E. Coli
  Biological Activity: Specific activity is 7-10 A650/min/mg, obtained by measuring the increase of insulin precipitation in absorbance at 650 nm resulting from the reduction of insulin.
  Product Introduction: Thioredoxins are small disulphide-containing redox proteins (within the conserved Cys-Gly-Pro-Cys active site) that have been found in all the kingdoms of living organisms. Thioredoxin contains a single disulfide active site and serves as a general protein disulphide oxidoreductase. Thioredoxins are involved in the first unique step in DNA synthesis. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of two cysteine thiol groups to a disulphide, accompanied by the transfer of two electrons and two protons. The net result is the covalent interconversion of a disulphide and a dithiol. It has been suggested that thioredoxin may catalyze the formation of correct disulfides during protein folding because of its ability to act as an efficient oxidoreductant. Trx also provides control over a number of transcription factors affecting cell proliferation and death through a mechanism referred to as redox regulation.
  Product Description: Thioredoxin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 125 amino acids (1-105 a.a.) and having a molecular mass of 13.9 kDa. TXN protein is fused to a 20 amino acid His-Tag at N-terminus and purified by standard chromatography.
• Reconstitution and Storage: Thioredoxin human although stable at 4C for 1 week, should be stored desiccated below -18C. Please prevent freeze thaw cycles.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Peptide Sequence: MGSSHHHHHH SSGLVPRGSH MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV.

Target Info

• Gene Symbol: TXN1
• Alias Symbols: R-Ras
• NCBI Gene Id: 6237
• Protein Name: Ras-related protein R-Ras
• Description of Target: Recombinant Human Thioredoxin His Tag
• Uniprot ID: P10301
• Protein Accession #: NP_006261.1
• Protein Size (# AA): Recombinant