TXN1 Protein (OPPA01444)

Catalog No: OPPA01444 (Formerly GWB-6FB2E7)

Size:10UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Thioredoxin (1mg/ml) solution containing 20mM phosphate buffer pH 7.4. Physical appearance: Sterile filtered colorless solution.
• Host: E. Coli
  Biological Activity: Specific activity is 7-10 A650/min/mg, obtained by measuring the increase of insulin precipitation in absorbance at 650 nm resulting from the reduction of insulin. Please refer to our activity assay protocol.
  Product Introduction: Thioredoxins are small disulphide-containing redox proteins (within the conserved Cys-Gly-Pro-Cys active site) that have been found in all the kingdoms of living organisms. Thioredoxin contains a single disulfide active site and serves as a general protein disulphide oxidoreductase. Thioredoxins are involved in the first unique step in DNA synthesis. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of two cysteine thiol groups to a disulphide, accompanied by the transfer of two electrons and two protons. The net result is the covalent interconversion of a disulphide and a dithiol. It has been suggested that thioredoxin may catalyze the formation of correct disulfides during protein folding because of its ability to act as an efficient oxidoreductant. Trx also provides control over a number of transcription factors affecting cell proliferation and death through a mechanism referred to as redox regulation.
  Product Description: Thioredoxin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 105 amino acids and having a molecular mass of 11.7 kDa.
• Reconstitution and Storage: Thyrodoxin human although stable at 4C for 1 week, should be stored desiccated below -18C. Please prevent freeze thaw cycles.
• Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Peptide Sequence: MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFFKKGQKVGEFS GANKEKLEAT INELV.

Target Info

• Gene Symbol: TXN1
• Alias Symbols: TRX, TRDX, TRX1, Trx80
• NCBI Gene Id: 7295
• Protein Name: Thioredoxin
• Description of Target: Recombinant Human Thioredoxin
• Uniprot ID: P10599
• Protein Accession #: NP_003320.2
• Protein Size (# AA): Recombinant