TUFM Antibody (OAAF03634)

Catalog No: OAAF03634 (Formerly GWB-ASE576)

Size:100 ug

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TUFM Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human TUFM.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: TUFM antibody detects endogenous levels of total TUFM protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: IHC: 1:50~1:100; ELISA: 1:40000
• Reference: Woriax V.L., Biochim. Biophys. Acta 1264:347-356(1995).
  Ling M., Gene 197:325-336(1997).
  Wells J., FEBS Lett. 358:119-125(1995).

Target Info

• Gene Symbol: TUFM
• Gene Full Name: Tu translation elongation factor, mitochondrial
• Alias Symbols: COXPD4;EF-Tu;EFTU;EF-TuMT;elongation factor Tu, mitochondrial;epididymis secretory sperm binding protein;P43.
• NCBI Gene Id: 7284
• Protein Name: Elongation factor Tu, mitochondrial
• Description of Target: Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.
• Uniprot ID: P49411
• Protein Accession #: NP_003312.3
• Molecular Weight: 49 kDa