TTR Antibody (OABB02140)

Catalog No: OABB02140

Size:100ug

Anti-Prealbumin Picoband antibody, OABB02140, Western blotting All lanes: Anti Prealbumin (OABB02140) at 0.5ug/ml Lane 1: Rat Liver Tissue Lysate at 50ug Lane 2: Mouse Liver Tissue Lysate at 50ug Lane 1: Mouse Testis Tissue Lysate at 50ug Predicted bind size: 14KD, 28KD, 55KD Observed bind size: 14KD, 28KD, 55KD

Anti-Prealbumin Picoband antibody, OABB02140, IHC(P) IHC(P): Mouse Pancreas Tissue

Anti-Prealbumin Picoband antibody, OABB02140, IHC(P) IHC(P): Rat Kidney Tissue

Product Info

• Tested Species Reactivity: Mouse, Rat
• Product Format: Lyophilized
• Clonality: Polyclonal
• Clone: Polyclonal
• Isotype: Rabbit IgG
• Host: Rabbit
• Application: WB, IHC-P
• Additional Information: Notes: Tested Species: In-house tested species with positive results.
  By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
  Other applications have not been tested.
  Optimal dilutions should be determined by end users.
  Background: Transthyretin (TTR) is also known as prealbumin. It is mapped to chromosome region 18q11.2-q12.1. This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease.
• Reconstitution and Storage: Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.. At -20C for one year from date of receipt. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for six months. Avoid repeated freezing and thawing.
• Immunogen: E.coli-derived mouse Prealbumin recombinant protein (Position: G21-N147). Mouse Prealbumin shares 81% and 94.5% amino acid (aa) sequence identity with human and rat Prealbumin, respectively.
• Purification: Immunogen affinity purified.
• Preservative: 0.05mg NaN3
• Specificity: No cross reactivity with other proteins.
• Application Info: Western blot: 0.1-0.5 ug/ml: Mouse, Rat
  Immunohistochemistry (Paraffin-embedded Section): 0.5-1 ug/ml: Mouse, Rat: By Heat
• Reference: 1. Benson, M. D., Dwulet, F. E. Identification of carriers of a variant plasma prealbumin (transthyretin) associated with familial amyloidotic polyneuropathy type I. J. Clin. Invest. 75: 71-75, 1985.
  2. Sparkes, R. S., Sasaki, H., Mohandas, T., Yoshioka, K., Klisak, I., Sakaki, Y., Heinzmann, C., Simon, M. I. Assignment of the prealbumin (PALB) gene (familial amyloidotic polyneuropathy) to human chromosome region 18q11.2-q12.1. Hum. Genet. 75: 151-154, 1987.
  
• Storage Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Description: Rabbit IgG polyclonal antibody for Transthyretin(TTR) detection. Tested with WB, IHC-P in Mouse;Rat.

Target Info

• Gene Symbol: TTR
• Gene Full Name: transthyretin
• Alias Symbols: Amyloid polyneuropathy, Amyloidosis I, ATTR, Carpal tunnel syndrome 1, CTS, CTS1, Dysprealbuminemic euthyroidal hyperthyroxinemia, Dystransthyretinemic hyperthyroxinemia, Epididymis luminal protein 111, HEL111, HsT2651, PALB, Prealbumin amyloidosis type I, Prealbumin, Prealbumin Thyroxine-binding, Senile systemic amyloidosis, TBPA, Thyroxine binding prealbumin, Transthyretin, TTHY_HUMAN, TTR, TTR protein
• NCBI Gene Id: 22139
• Protein Name: Transthyretin
• Description of Target: This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease.
• Uniprot ID: P07309
• Protein Accession #: NP_038725.1
• Nucleotide Accession #: NM_013697.5
• Protein Size (# AA): 147
• Molecular Weight: 16 kDa