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Catalog No: OASE00140-Biotin
Size:100ug
Price: $399.00
SKU
OASE00140-Biotin
Availability: Domestic: within 3-5 days delivery | International: 3-5 days
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Tsp23 Antibody : Biotin (OASE00140-Biotin)

Datasheets/ManualsPrintable datasheet for OASE00140-Biotin
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer.
ClonalityMonoclonal
CloneTsp232A
IsotypeIgG1 Kappa
HostMouse
ConjugationBiotin
ApplicationWB
Additional InformationBackground Info: Detects ~19kDa. Detects Tsp23, no cross-reactivity to p23.
::Scientific Background: p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the
hsp90 chaperoning system (1). Studies have revealed that
p23 is a small protein (18 to 25 kDa) with a simple
structure (2, 3). p23 is a phosphor-protein, which is highly
acidic and has an aspartic acid-rich c-terminal domain
(1). Numerous studies have found p23 to be associated
with other client proteins like Fes tyrosine kinase (4), the
heme regulated kinase HRI (5), hsf1 transcription factor
(4), aryl hydrocarbon receptor (4), telomerase (6), and
Hepadnavirus reverse transcriptase (7). In spite of several
years of study, the exact functional significance of p23 is
still not clear (8). p23 is thought to be involved in the
adenosine triphosphate–mediated hsp90 binding of client
proteins (8). Since many hsp90 client proteins are
involved in oncogenic survival signaling, a recent study
has concluded p23 to be a promising target in leukemic
apoptosis (9). Hsp90 and its co-chaperone p23 are certainly
among the emerging anti-tumor targets in oncology.
Specifically TSP23 (transcript similar p23) displays 44% and
17% amino acid identity with p23 and Sba1p respectively
(10).
::Certificate of Analysis: 1 ug/mL was sufficient for detection of tsp23 in 20ug of transiently transfected Hela cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Reconstitution and StorageAll conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
ImmunogenRecombinant tsp23
PurificationProtein G Purified
Concentration1 mg/ml
Dilution1:1000 (WB)
Storage BufferPBS pH7.4, 50% glycerol
Reference1. Johnson J.L., Beito T. G., Krco C.J., Toft D.O. (1994) Mol Cell Biol 14: 1956-63.
2. Weikl T., Abelmann K., Buchner J. (1999) J Mol Biol
293: 685-91.
3. Weaver A.J., Sullivan W.P., Felts S.J., Owen B.A.,
Toft D.O. (2000) J Biol Chem 275: 23045-52.
4. Nair S.C., et al. (1996) Cell Stress Chaperones 1: 237-50.
5. Xu Z., et al. (1997) Eur J Biochem 246, 461-70.
6. Holt S.E., et al. (1999) Genes Dev 13: 817-26.
7. Hu J., Toft D., Anselmo D., Wang X. (2002) J Virol
76: 269-79.
8. Felts, S.J., Toft D.O. (2003) Cell Stress Chaperones.8: 108-
13.
9. Gausdal G., Gjertsen B.T., Fladmark K.E., Demol H.,
Vandekerckhove J. & Doskeland S.O. (2004) Leukemia
10. Freeman B.C., Felts S.J., Toft D.O., Yamamato K.R.
(2000) Genes Dev. 14(4): 433-434.
Gene SymbolAARSD1
Gene Full Namealanyl-tRNA synthetase domain containing 1
Alias SymbolsAlaXp
NCBI Gene Id80755
Uniprot IDB9A003
Protein Accession #NP_001136126.1
  1. What is the species homology for "Tsp23 Antibody : Biotin (OASE00140-Biotin)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "Tsp23 Antibody : Biotin (OASE00140-Biotin)"?

    This item is available "Domestic: within 3-5 days delivery | International: 3-5 days".

  3. What buffer format is "Tsp23 Antibody : Biotin (OASE00140-Biotin)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Tsp23 Antibody : Biotin (OASE00140-Biotin)"?

    This target may also be called "AlaXp" in publications.

  5. What is the shipping cost for "Tsp23 Antibody : Biotin (OASE00140-Biotin)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Tsp23 Antibody : Biotin (OASE00140-Biotin)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Tsp23 Antibody : Biotin (OASE00140-Biotin)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Tsp23 Antibody : Biotin (OASE00140-Biotin)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "AARSD1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "AARSD1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "AARSD1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "AARSD1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "AARSD1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "AARSD1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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