TSHR Antibody - C-terminal region : Biotin (ARP41871_P050-Biotin)

Catalog No: ARP41871_P050-Biotin

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Biotin
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TSHR
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 83%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 86%; Rat: 93%; Sheep: 79%
• Peptide Sequence: Synthetic peptide located within the following region: KLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLLPLGRKSLSFETQKAPRSS
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-TSHR (ARP41871_P050-Biotin) antibody is Catalog # AAP41871 (Previous Catalog # AAPP24408)
• Sample Type Confirmation:

  There is BioGPS gene expression data showing that TSHR is expressed in Jurkat

• Reference: Claus,M., (2005) Endocrinology 146 (12), 5197-5203
• Publications:

  Pessina, P., Castillo, V., Sartore, I., Borrego, J. & Meikle, A. Semiquantitative immunohistochemical marker staining and localization in canine thyroid carcinoma and normal thyroid gland. Vet. Comp. Oncol. (2014). doi:10.1111/vco.12111 IHC, Human, Horse, Rat, Dog, Rabbit, Guinea pig, Mouse, Bovine, Sheep 25082554

Target Info

• Gene Symbol: TSHR
• Gene Full Name: Thyroid stimulating hormone receptor
• Alias Symbols: LGR3, CHNG1, hTSHR-I
• NCBI Gene Id: 7253
• Protein Name: Thyrotropin receptor
• Description of Target: TSHR is receptor for thyrothropin. It plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. It also acts as a receptor for thyrostimulin (GPA2+GPB5).
• Uniprot ID: Q96GT6
• Protein Accession #: NP_001018046
• Nucleotide Accession #: NM_001018036
• Protein Size (# AA): 253
• Molecular Weight: 28kDa
• Protein Interactions: ADRB2; SCRIB; UBC; TSHB; RABAC1; GNA13; GNA12; FLNB; TSHR; GNAQ; PIK3R1; LHCGR; JAK2; JAK1; GNAI3; GNAI2; GNAS; GNA11; GNAO1; GNAI1; HSPA5; FN1; CANX; CALR; STAT3; CALCR;