TRPM7 Antibody - C-terminal region (OAAB17411)

Catalog No: OAAB17411 (Formerly GWB-KZZMWB)

Size:400ul

Western blot analysis of anti-CHAK1 Antibody (C-term) (Cat.# OAAB17411) in mouse kidney tissue lysates (35ug/lane). CHAK1 (arrow) was detected using the purified Pab.

CHAK1 Antibody (F1835) (Cat. # OAAB17411) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CHAK1 antibody detected the CHAK1 protein (arrow).

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC
• Additional Information: Precautions: TRPM7 (CHAK1) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell Phosphorylates annexin A1 (ANXA1)
  Cellular Location: Membrane; Multi-pass membrane protein (Probable)
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This TRPM7 (CHAK1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1821-1850 amino acids from the C-terminal region of human TRPM7 (CHAK1).
• Predicted Homology Based on Immunogen Sequence: Human; Mouse
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:1000
  IHC-P: 1:50~100

Target Info

• Gene Symbol: TRPM7
• Alias Symbols: CHAK, CHAK1, ALSPDC, LTRPC7, LTrpC-7, TRP-PLIK
• NCBI Gene Id: 54822
• Protein Name: Transient receptor potential cation channel subfamily M member 7
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: Q96QT4
• Protein Accession #: NP_060142.3
• Molecular Weight: 212697 Da