TRPC6 Antibody (OARA02194)

Catalog No: OARA02194

Size:25UL

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid (sterile filtered)
• Clonality: Monoclonal
• Clone: 3F2.H10.F2
• Host: Mouse
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot
• Additional Information: Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
  Label: Unconjugated
  Preservative: 0.01% (w/v) Sodium Azide
  Stabilizer: None
• Reconstitution and Storage: -20°C|See manual
• Immunogen: This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminus of human TRPC6 protein.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: 1 mg/ml
• Application Info: ELISA: 1:10,000 - 1:50,000 WB: 1:500- 1:2,000 IHC: 2.5 ug/mL
• Reference: Hofmann T., Obukhov A.G., Schaefer M., Harteneck C., Gudermann T., Schultz G. (1999). Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397:259-263.D'Esposito M., Strazzullo M., Cuccurese M., Spalluto C., Rocchi M., D'Urso M., Ciccodicola A. (1998). Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-22. Cytogenet. Cell Genet. 83:46-47.Reiser J., Polu K.R., Moller C.C., Kenlan P., Altintas M.M., Wei C., Faul C., Herbert S., Villegas I., Avila-Casado C., McGee M., Sugimoto H., Brown D., Kalluri R., Mundel P., Smith P.L., Clapham D.E., Pollak M.R. (2005) TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat. Genet. 37:739-744.

Target Info

• Gene Symbol: TRPC6
• Gene Full Name: transient receptor potential cation channel subfamily C member 6
• Alias Symbols: focal segmental glomerulosclerosis 2;FSGS2;short transient receptor potential channel 6;transient receptor protein 6;TRP6;TRP-6.
• NCBI Gene Id: 7225
• Protein Name: Short transient receptor potential channel 6
• Description of Target: Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.
• Uniprot ID: Q9Y210
• Protein Accession #: NP_004612.2
• Nucleotide Accession #: NM_004621.5