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TRPC6 Antibody (OAEB00820)

100 ug
$349.00
In Stock
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Predicted Species Reactivity:
Horse, Human, Pig, Rabbit
Product Format:
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Clonality:
Polyclonal
Host:
Goat
Application:
ELISA, FC
Additional Information:
Reactivity Info: Tested: Mouse; Expected: Human, Dog, Cow
Reconstitution and Storage:
Aliquot and store at -20C. Minimize freezing and thawing.
Gene Symbol:
TRPC6
NCBI Gene Id:
7225
Protein Name:
Short transient receptor potential channel 6
Swissprot Id:
Q9Y210
Protein Accession #:
NP_004612.2
Replacement Item:
This antibody may replace item sc-15056 from Santa Cruz Biotechnology.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express TRPC6.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express TRPC6.
Predicted Homology Based on Immunogen Sequence:
Horse: 92%; Human: 100%; Pig: 100%; Rabbit: 84%
Complete computational species homology data:
TRPC6 Antibody (OAEB00820)
Peptide Sequence:
C-EKLSMEPNQEETN
Datasheets/Manuals:
Printable datasheet for anti-TRPC6 antibody - OAEB00820
Purity:
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Application Info:
Peptide ELISA: antibody detection limit dilution 1:2000.
Western Blot: Preliminary experiments gave an approx 80kDa band in Human Spleen and Testis lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 106kDa according to NP_004612.2. The 80kDa band was successfully blocked by incubation with the immunizing peptide.
Target Reference:
* Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB.; A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis.; Science. 2005 Jun 17;308(5729):1801-4. Epub 2005 May 5.; Pubmed 15879175

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