TRPC3 Antibody (OAPB00439)

Catalog No: OAPB00439

Size:100UG

Western blot analysis of TRPC3 in mouse heart tissue lysate with TRPC3 antibody at (A) 1 and (B) 2 ug/mL.

Immunohistochemistry of TRPC3 in mouse heart tissue with TRPC3 antibody at 10 ug/mL.

Product Info

• Predicted Species Reactivity: Human|Rat
• Product Format: Liquid. TRPC3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: ELISA, IHC-P, WB
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: TRPC3 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: TRPC3 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human TRPC3. The immunogen is located within amino acids 120 - 170 of TRPC3.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-TRPC3 (OAPB00439) antibody is Catalog # OEPB02540
• Application Info: TRPC3 antibody can be used for the detection of TRPC3 by Western blot at 0.5 - 1 ug/ml. (Optimal dilution should be determined by user)

Target Info

• Reference: Contell C, Birnbaumer V, Flockerzi V, et al. A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 2002; 9:229-31.;Trebak M, Vazquez G, Bird GSJ, et al. The TRPC3/6/7 subfamily of cation channels. Cell Calcium 2003; 33:451-61.;Zitt C, Obukhov AG, Strubing C, et al. Expression of TRPC3 in Chinese hamster ovary cells results in calcium-activated cation currents not related to store depletion. J. Cell. Biol. 1997; 1333-41.;
• Gene Symbol: TRPC3
• Gene Full Name: transient receptor potential cation channel subfamily C member 3
• Alias Symbols: hTrp-3;SCA41;short transient receptor potential channel 3;transient receptor potential cation channel subfamily C member 3 variant c;transient receptor protein 3;TRP3.
• NCBI Gene Id: 7222
• Protein Name: Short transient receptor potential channel 3|transient receptor potential related channel 3 protein [Homo sapiens]
• Description of Target: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
• Uniprot ID: Q13507
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/CAA74083
• Nucleotide Accession #: NM_001130698.1; NM_003305.2
• Molecular Weight: Predicted: 93 kDa Observed: 100 kDa