TREM2 Antibody - N-terminal region (OAAB02883)

Catalog No: OAAB02883

Size:200ul

TREM2 Antibody (N-term) western blot analysis in MDA-MB435 cell lysates (35ug/lane).This demonstrates the TREM2 antibody detected the TREM2 protein (arrow).

TREM2 is strongly supported by BioGPS gene expression data to be expressed in MDA-MB435

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
  Function: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.
  Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.
  Tissue Location Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.
  
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This TREM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between a range from 22-50 amino acids of human TREM2.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Sample Type Confirmation:

  TREM2 is strongly supported by BioGPS gene expression data to be expressed in MDA-MB435

• Intended Use: For research use only and not for use in diagnostic or therapeutic procedures.
  
• Application Info: WB: 1:1000

Target Info

• Gene Symbol: TREM2
• Alias Symbols: PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c
• NCBI Gene Id: 54209
• Protein Name: Triggering receptor expressed on myeloid cells 2
• Description of Target: TREM2 is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL).
  
• Uniprot ID: Q9NZC2
• Protein Accession #: NP_061838.1
• Molecular Weight: 25447 Da