TREM1 Antibody - PE Conjugated (OASA11339)

Catalog No: OASA11339 (Formerly GWB-Q01568)

Size:100T

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: Lyophilized. Phosphate buffered saline
• Clonality: Monoclonal
• Clone: L5-B8.2A12.3A12
• Isotype: IgG2a
• Host: Rat
• Conjugation: R-PE
• Application: FC
• Additional Information: Buffer Solutions: Phosphate buffered saline
  Preservative Stabilisers: 0.09%Sodium Azide (NaN3), 1%Bovine Serum Albumin
  
• Reconstitution and Storage: 2°C to 8°C
• Immunogen: Mouse TREM-1 Fc fusion protein.
• Purification: Protein G Purified
• Predicted Homology Based on Immunogen Sequence: Mouse
• Specificity: Rat anti Mouse Trem-1 antibody, clone L5-B8.2A12.3A12 recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes, leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes, which is reported to act as an inhibitor of TREM-1.
  TREM-1 mediates the septic shock pathway, and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection.
  
• Application Info: Flow Cytometry - neat. Use 10ul of the suggested working dilution to label 1x10⁶ cells in 100ul.
  

Target Info

• Alias Symbols: triggering receptor expressed in monocytes 1, triggering receptor expressed on myeloid cells 1.
• NCBI Gene Id: 58217
• Protein Name: Triggering receptor expressed on myeloid cells 1
• Description of Target: RAT ANTI MOUSE TREM-1:RPE
• Uniprot ID: Q9JKE2
• Protein Accession #: NP_067381.1