Aviva Systems Biology will be closed in observance of Good Friday 3/29/2024. If you are in need of any assistance please email info@avivasysbio.com

Catalog No: OPED00146
Size:200 ug
Price: $593.00
SKU
OPED00146
Availability: Domestic: within 1-2 week delivery | International: 1-2 week
Bulk
Order
Aviva's
Satisfaction
Guarantee
Contact Us:
Shipping Info:
  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
  • Contact us for international orders.
Datasheets/ManualsPrintable datasheet for TRAP1 Recombinant Protein (Human) (OPED00146) (OPED00146)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatLiquid. In 50mM TRIS, pH 7.5, containing 150mM sodium chloride, 1mM DTT, and 1mM EDTA.
HostE. Coli
ApplicationWB
Additional InformationThe Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress. It includes cytoplasmic (Hsp90-alpha /beta ), ER (Grp94) and mitochondrial (TRAP1) localized members. Hsp90 is structurally composed of an N-terminal ATP binding domain, a medial substrate-binding region, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones to stabilize a multitude of client proteins substrates. TRAP1 (aka Hsp75) was originally identified as a chaperone binding partner for retinoblastoma protein. TRAP1 was later found by immunofluorescence to be localized to the mitochondria. TRAP1 is significantly more active as an ATPase due in part to the lack of regulatory elements in the C-terminus, but retains the ability to dimerize. However, it does not form stable complexes with typical cochaperones of Hsp90 like p23 and HOP4. TRAP1 has been identified as a protective element for cell survival, and has been suggested as a target for anti-cancer therapeutics.
Reconstitution and StorageStore at -80C
PurificationPurified by multi-step chromatography.
Purity>95% (SDS-PAGE; Western blot)
Application InfoWestern blot control.
Gene SymbolTRAP1
Gene Full NameTNF receptor associated protein 1
Alias Symbolsheat shock protein 75 kDa, mitochondrial;HSP 75;HSP75;HSP90L;testicular tissue protein Li 209;TNFR-associated protein 1;TRAP-1;tumor necrosis factor type 1 receptor-associated protein.
NCBI Gene Id10131
Protein NameHeat shock protein 75 kDa, mitochondrial
Description of TargetChaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Uniprot IDQ12931
Protein Size (# AA)Recombinant
Molecular Weight72 kDa
Write Your Own Review
You're reviewing:TRAP1 Recombinant Protein (Human) (OPED00146)
Your Rating
We found other products you might like!