Transthyretin Antibody (OAPB00883)

Catalog No: OAPB00883

Size:0.1 mg

Western blot analysis of Transthyretin in human lung tissue lysate with Transthyretin antibody at (A) 1 and (B) 2 ug/mL.

Western blot analysis of Transthyretin in HepG2 cell lysate with Transthyretin antibody at (A) 1 and (B) 2 ug/ml.

Immunohistochemistry of Transthyretin in human lung tissue with Transthyretin antibody at 2.5 ug/mL.

Product Info

• Tested Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid PBS containing 0.02% sodium azide
• Clonality: Polyclonal
• Isotype: IgY
• Host: Chicken
• Application: WB, IHC-P, IF
  Positive Controls: HepG2 cell lysate, Human Lung Tissue
• Reconstitution and Storage: Transthyretin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies, care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: The immunogen for anti-Transthyretin antibody: antibody was raised against a 17 amino acid peptide near the center of human Transthyretin. The immunogen is located within amino acids 40 - 90 of Transthyretin.
• Purification: Transthyretin Antibody is affinity chromatography purified via peptide column.
• Predicted Homology Based on Immunogen Sequence: Bovine (94%), Sheep (88%), Rabbit (82%), Pig (82%)
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-Transthyretin antibody is Catalog # OEPB03005
• Application Info: WB: 1-2 ug/mL
  IHC: 2.5 ug/mL
  IF: 20 ug/mL
• Reference: Fleming CE, Nunes AF, and Sousa MM. Transthyretin: more than meets the eye. Prog. Neurobiol.2009; epub.;Fleming CE, Saraiva MJ, and Sousa MM. Transthyretin enhances nerve regeneration. J. Neurochem.2007; 103:831-9.;Rite I, Arguelles S, Venero JL, et al. Proteomic identification of biomarkers in the cerebrospinal fluid in a rat model of nigrostriatal dopaminergic degeneration. J. Neurosci. Res.2007; 85:3607-18. ;

Target Info

• Gene Symbol: TTR
• Alias Symbols: CTS, TTN, ATTR, CTS1, PALB, TBPA, HEL111, HsT2651
• NCBI Gene Id: 7276
• Protein Name: Transthyretin
• Description of Target: Transthyretin Antibody: Transthyretin is a tetrameric carrier protein that transports thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. The diseases caused by mutations include familial amyloidotic polyneuropathy, euthyroid hyperthyroxinemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. It has also been suggested that Transthyretin plays an important role in the maintenance of normal cognitive processes during aging, neuropeptide processing and nerve regeneration. It has also been linked to several pathological conditions including Parkinson's disease, schizophrenia, and depression.
• Uniprot ID: P02766
• Molecular Weight: 16 kDa