TRAF6 Recombinant Protein (OPCD07701)

Catalog No: OPCD07701

TRAF6 Recombinant Protein (OPCD07701) using SDS-PAGE

TRAF6 Recombinant Protein (OPCD07701) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gln254-Asn475
  Subcellular Location: Cytoplasm.
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Traf6
• Gene Full Name: TNF receptor-associated factor 6
• Alias Symbols: 2310003F17Rik;AI851288;C630032O20Rik;E3 ubiquitin-protein ligase TRAF6;RING-type E3 ubiquitin transferase TRAF6;TNF receptor-associated factor 6.
• NCBI Gene Id: 22034
• Protein Name: TNF receptor-associated factor 6
• Description of Target: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.
• Uniprot ID: P70196
• Protein Accession #: NP_001290202.1
• Nucleotide Accession #: NM_001303273.1
• Protein Size (# AA): Leu210~Pro473
• Molecular Weight: 34kDa