TRAF2 Recombinant Protein (OPCD07697)

Catalog No: OPCD07697

TRAF2 Recombinant Protein (OPCD07697) using SDS-PAGE

TRAF2 Recombinant Protein (OPCD07697) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Isoelectric Point: 7.1
  Residues: Gln238-Phe491
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Traf2
• Gene Full Name: TNF receptor-associated factor 2
• Alias Symbols: AI325259;E3 ubiquitin-protein ligase TRAF2;RING-type E3 ubiquitin transferase TRAF2;TNF receptor-associated factor 2.
• NCBI Gene Id: 22030
• Protein Name: TNF receptor-associated factor 2
• Description of Target: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
• Uniprot ID: P39429
• Protein Accession #: NP_001277342.1
• Nucleotide Accession #: NM_001290413.1
• Protein Size (# AA): Gln238~Phe491
• Molecular Weight: 32kDa