TPO Antibody (OASL01252)

Catalog No: OASL01252

Size:50ul

Immunohistochemical analysis of paraffin-embedded Follicular thyroid carcinoma. 1, Antibody was diluted at 1:200 (4C, overnight) . 2, Citric acid ,pH6.0 was used for antigen retrieval.

Immunohistochemical analysis of paraffin-embedded Follicular thyroid carcinoma. 1, Antibody was diluted at 1:200 (4C, overnight) . 2, Citric acid ,pH6.0 was used for antigen retrieval.

Product Info

• Product Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Monoclonal
• Isotype: IgG2b, Kappa
• Host: Mouse
• Application: IHC-P
• Additional Information: Background: thyroid peroxidase(TPO) Homo sapiens this gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
  Function: alternative products: Additional isoforms seem to exist, catalytic activity: 2 iodide + H(2)O(2) + 2 H(+) = 2 iodine + 2 H(2)O, cofactor: binds 1 calcium ion per heterodimer, cofactor: binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer, disease: An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease, disease: defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM: 274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete, Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4), online information: thyroid peroxidase entry, pathway: hormone.
  Location: cytoplasmic
  Expression: Glandular pool- thyroid, Spleen, Thyroid.
• Reconstitution and Storage: Store at -20C for one year. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human Thyroid Peroxidase(TPO)
• Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
• Concentration: 1 mg/ml
• Specificity: This antibody detects endogenous levels of human Thyroid Peroxidase(TPO)
• Application Info: IHC-P 1:100 - 200

Target Info

• Gene Symbol: TPO
• Alias Symbols: MSA, TPX, TDH2A
• NCBI Gene Id: 7173
• Protein Name: Thyroid peroxidase (TPO) (EC 1.11.1.8)
• Uniprot ID: P07202