tPA Protein (OPPA00785)

Catalog No: OPPA00785 (Formerly GWB-2067B9)

Size:20UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Lyophilized Each mg of tPA contains 1.7 grams L-arginine, 0.5 g phosphoric acid and 4 mg tween 80
  Physical Appearance: Sterile filtered white freeze-dried powder
• Reconstitution and Storage: It is recommended to reconstitute the lyophilized tPA in sterile 18M-omega-cm H₂O not less than 100 ug/mL, which can then be further diluted to other aqueous solutions. Lyophilized tPA, although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution, tPA should be stored at 4°C between 2-7 days and for further use below -18°C. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze/thaw cycles.
• Purification: Purified by proprietary chromatographic techniques.
• Purity: Greater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Biological Activity: Enzymatic Activity: 580,000 IU/mg.
• Source: Chinese Hamster Ovarian Cells (CHO)

Target Info

• Gene Symbol: tPA
• Alias Symbols: TPA, T-PA
• NCBI Gene Id: 5327
• Protein Name: Tissue-type plasminogen activator
• Description of Target: Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine protease which converts plasminogen into plasmin, a fibrinolyticenzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysiswhich can result in thrombosisor embolism. Tissue Plasminogen Activator Human Recombinant produced in CHO cells is a single, glycosylated polypeptide chain containing 527 amino acids.
• Uniprot ID: P00750
• Protein Accession #: NP_000921.1
• Protein Size (# AA): Recombinant
• Molecular Weight: 59 kDa