TP73 Antibody (Acetyl-Lys321) (OASG00153)

Catalog No: OASG00153

Size:100 uL

Western Blot using K562

Western Blot using K562

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC-P
  Cellular Localization: Nucleus Cytoplasm. Accumulates in the nucleus in response to DNA damage.
  Tissue Specificity: Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.
  Sequence & Domain Family: Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL1 tyrosine kinase SH3 domain. The WW-binding motif mediates interaction with WWOX.
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the human p73 around the acetylation site of K321.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Acetyl-Lys321
• Specificity: Acetyl-p73 (K321) Polyclonal Antibody detects endogenous levels of p73 protein only when acetylated at K321.
• Application Info: WB: 1:500~2000
  IHC-P: 1:100~300
  ELISA: 1:20000

Target Info

• Gene Symbol: TP73
• Gene Full Name: tumor protein p73
• Alias Symbols: P73
• NCBI Gene Id: 7161;
• Description of Target: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
• Uniprot ID: O15350
• Molecular Weight: 70 kDa