Size:100 ul
Special Price $229.00 Regular Price $289.00
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ARP30311_P050
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Conjugation Options

ARP30311_P050-FITC Conjugated

ARP30311_P050-HRP Conjugated

ARP30311_P050-Biotin Conjugated

TP53 Antibody - N-terminal region (ARP30311_P050)

Catalog#: ARP30311_P050
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species Reactivity Human
Predicted Species Reactivity Human
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application CHIP, IHC, WB
Additional Information IHC Information: Kidney
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-126 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human TP53
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Human: 100%
Complete computational species homology data Anti-TP53 (ARP30311_P050)
Peptide Sequence Synthetic peptide located within the following region: EEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIE
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-TP53 (ARP30311_P050) antibody is Catalog # AAP30311 (Previous Catalog # AAPS08801)
Datasheets/Manuals Printable datasheet for anti-TP53 (ARP30311_P050) antibody
Sample Type Confirmation

TP53 is strongly supported by BioGPS gene expression data to be expressed in DU145, HEK293T

Target Reference Boehme,K.A., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (22), 7785-7790
Gene Symbol TP53
Alias Symbols LFS1, TRP53, p53
NCBI Gene Id 7157
Protein Name Cellular tumor antigen p53
Description of Target TP53 acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Swissprot Id P04637
Protein Accession # NP_000537
Nucleotide Accession # NM_000546
Protein Size (# AA) 393
Molecular Weight 44kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express TP53.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express TP53.
  1. What is the species homology for "TP53 Antibody - N-terminal region (ARP30311_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "TP53 Antibody - N-terminal region (ARP30311_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "TP53 Antibody - N-terminal region (ARP30311_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TP53 Antibody - N-terminal region (ARP30311_P050)"?

    This target may also be called "LFS1, TRP53, p53" in publications.

  5. What is the shipping cost for "TP53 Antibody - N-terminal region (ARP30311_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TP53 Antibody - N-terminal region (ARP30311_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "TP53 Antibody - N-terminal region (ARP30311_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "44kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TP53 Antibody - N-terminal region (ARP30311_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "TP53"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "TP53"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "TP53"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "TP53"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "TP53"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "TP53"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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