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Catalog No: OACA02087
Size:100ug
Price: $329.00
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OACA02087
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TP53 Antibody - FITC Conjugated (OACA02087)

Datasheets/ManualsPrintable datasheet for TP53 Antibody - FITC Conjugated (OACA02087) (OACA02087)
Product Info
Predicted Species ReactivityRat
Product FormatLiquid
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationFITC
ApplicationWB
Reconstitution and Storage-20°C or -80°C
ImmunogenRecombinant Rat Cellular tumor antigen p53 protein (1-391AA)
PurificationProtein G Purified
PurityCaprylic Acid Ammonium Sulfate Precipitation purified
Reference[1] cDNA cloning and immunological characterization of rabbit p53.'le Goas F., May P., Ronco P., Caron de Fromentel C.Gene 185:169-173(1997)
[2] Mcbride OW, Merry D, Givol D. The gene for p53 cellular tumor antigen is located on chromosome 17 short arm (17P13).' Proc Natl Acad Sci USA,  1986;83(1):130-134
[3] Mathews MB. Identity of the proliferating cell nuclear antigen and cyclin.' Nature, 1984;309(11):374-378
Storage BufferPreservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Gene SymbolTp53
Gene Full Nametumor protein p53
Alias Symbolscellular tumor antigen p53;p53;transformation related protein 53;Trp53;tumor protein p53 (Li-Fraumeni syndrome);tumor suppressor p53.
NCBI Gene Id24842
Protein NameCellular tumor antigen p53
Description of TargetActs as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
Uniprot IDP10361
Protein Accession #NP_000537.3; NP_001119584.1; NP_001119585.1; NP_001119586.1; NP_001119587.1; NP_001119588.1
Nucleotide Accession #NM_000546.5; NM_001126112.2; NM_001126113.2; NM_001126114.2; NM_001126115.1; NM_001126116.1
  1. What is the species homology for "TP53 Antibody - FITC Conjugated (OACA02087)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Rat".

  2. How long will it take to receive "TP53 Antibody - FITC Conjugated (OACA02087)"?

    This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".

  3. What buffer format is "TP53 Antibody - FITC Conjugated (OACA02087)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TP53 Antibody - FITC Conjugated (OACA02087)"?

    This target may also be called "cellular tumor antigen p53;p53;transformation related protein 53;Trp53;tumor protein p53 (Li-Fraumeni syndrome);tumor suppressor p53." in publications.

  5. What is the shipping cost for "TP53 Antibody - FITC Conjugated (OACA02087)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TP53 Antibody - FITC Conjugated (OACA02087)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "TP53 Antibody - FITC Conjugated (OACA02087)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TP53 Antibody - FITC Conjugated (OACA02087)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "Tp53"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "Tp53"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "Tp53"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "Tp53"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "Tp53"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "Tp53"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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