Size:100 ul
Special Price $229.00 Regular Price $249.00
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SKU
AMM00024
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TP53 Antibody (AMM00024)

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Catalog#: AMM00024
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More Information
Tested Species Reactivity Human
Predicted Species Reactivity Human
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Monoclonal
Isotype Mouse IgG
Host Mouse
Application CHIP, WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-126 from Santa Cruz Biotechnology.
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Datasheets/Manuals Printable datasheet for anti-TP53 (AMM00024) antibody
Sample Type Confirmation

TP53 is supported by BioGPS gene expression data to be expressed in Daudi

Target Reference Khanna,K.K., et al., Nat. Genet. 20 (4), 398-400 (1998)
Gene Symbol TP53
Alias Symbols P53, LFS1, TRP53, FLJ92943, TP53
NCBI Gene Id 7157
Protein Name Cellular tumor antigen p53
Description of Target Tumor protein p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome
Swissprot Id P04637
Protein Accession # NP_000537
Nucleotide Accession # NM_000546
Protein Size (# AA) 393
Molecular Weight 53kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express TP53.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express TP53.
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