Size:100 ul
Special Price $229.00 Regular Price $249.00
Discontinued
SKU
AMM00023
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TP53 Antibody (AMM00023)

Catalog#: AMM00023
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Tested Species ReactivityHuman
Predicted Species ReactivityHuman
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityMonoclonal
IsotypeMouse IgG
HostMouse
ApplicationCHIP, WB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement ItemThis antibody may replace item sc-126 from Santa Cruz Biotechnology.
ConcentrationBatch dependent within range: 100 ul at 0.5 - 1 mg/ml
Datasheets/ManualsPrintable datasheet for anti-TP53 (AMM00023) antibody
Sample Type Confirmation

TP53 is strongly supported by BioGPS gene expression data to be expressed in DU145

Target ReferenceKhanna,K.K., et al., Nat. Genet. 20 (4), 398-400 (1998)
Gene SymbolTP53
Alias SymbolsP53, LFS1, TRP53, FLJ92943, TP53
NCBI Gene Id7157
Protein NameCellular tumor antigen p53
Description of TargetTumor protein p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome
Swissprot IdP04637
Protein Accession #NP_000537
Nucleotide Accession #NM_000546
Protein Size (# AA)393
Molecular Weight53kDa
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express TP53.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express TP53.
  1. What is the species homology for "TP53 Antibody (AMM00023)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "TP53 Antibody (AMM00023)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "TP53 Antibody (AMM00023)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TP53 Antibody (AMM00023)"?

    This target may also be called "P53, LFS1, TRP53, FLJ92943, TP53" in publications.

  5. What is the shipping cost for "TP53 Antibody (AMM00023)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TP53 Antibody (AMM00023)"?

    All Aviva products have been through vigorous validations and carry 100% satisfaction warranty.

  7. Can I get bulk pricing for "TP53 Antibody (AMM00023)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "53kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TP53 Antibody (AMM00023)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "TP53"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "TP53"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "TP53"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "TP53"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "TP53"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "TP53"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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