Catalog No: OPCA03204
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OPCA03204
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Product Info
Predicted Species ReactivityBlack Mamba|Dendroaspis polylepis
Product FormatLiquid or Lyophilized powder
HostDendroaspis polylepis polylepis
Additional InformationRelevance: Potently contracts gastrointestinal (GI) smooth muscle. The receptor for this toxin is present both in the CNS and in the smooth muscle and may be a potassium channel.
Reconstitution and Storage-20°C or -80°C
Formulation20 mM Tris-HCl based buffer, pH 8.0
PurityGreater than 90% as determined by SDS-PAGE.
Peptide SequenceAVITGACERDLQCGKGTCCAVSLWIKSVRVCTPVGTSGEDCHPASHKIPFSGQRMHHTCPCAPNLACVQTSPKKFKCLSKS
Protein SequenceAVITGACERDLQCGKGTCCAVSLWIKSVRVCTPVGTSGEDCHPASHKIPFSGQRMHHTCPCAPNLACVQTSPKKFKCLSKS
Storage BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
SourceE.coli
Protein Range1-81 aa
TagN-terminal 6xHis-SUMO-tagged
ReferenceMIT1, a black mamba toxin with a new and highly potent activity on intestinal contraction.Schweitz H., Pascaud P., Diochot S., Moinier D., Lazdunski M.FEBS Lett. 461:183-188(1999)
Alias SymbolsBlack mamba intestinal toxin 1;Black mamba venom protein A.
Protein NameToxin MIT1
Description of TargetPotent agonist for both PKR1/PROKR1 and PKR2/PROKR2 (PubMed:12054613). Potently contracts gastrointestinal (GI) smooth muscle (PubMed:10567694).
Uniprot IDP25687
Protein Size (# AA)Recombinant
Molecular Weight24.6 kDa
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