Catalog No: OOPA00090 (Formerly GWB-BSP320)
Size:5UG
Price: $75.00
SKU
OOPA00090
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TOP1 70kDa Protein (OOPA00090)

Datasheets/ManualsPrintable datasheet for OOPA00090
Product Info
HostSf9 insect cells.
::Product Introduction: TOP1 is an important nuclear enzyme that interconverts supercoiled DNA to the necessary topological conformations for standard DNA replication and transcription. TOP1 is the target antigen for TOP1 autoantibodies. TOP1 antibodies are a specific marker in scleroderma patients (specificity 98-100%) and are related with the existence of diffuse skin involvement and pulmonary fibrosis. In human tissues top1 enzyme is primarily synthesized as a protein with a molecular weight of 100-kDa. Most of this precursor is then proteolytically processed to a 70-kDa size, from which the TOP1 antigen has derived its name.
Product Description: Recombinant TOP1 70kDa protein is an enzyme fragment having a molecular mass of 69,199 Dalton (pH 9.4). TOP1 70kDa protein is fused to a hexa-histidine purification tag.
PurityGreater than 80% as determined by SDS-PAGE.
Application InfoWestern blot with Scleroderma patient sera or monoclonal anti-hexa-His-tag antibody.
FormulationTOP1 70kDa is supplied in 16mM HEPES buffer pH-8.0, 400mM NaCl, and 20% glycerol.
PurificationGreater than 80% as determined by SDS-PAGE.
Gene SymbolTOP1 70kDa
Alias SymbolsDNA topoisomerase 1, EC 5.99.1.2, DNA topoisomerase I, TOP1, Scl-70.
Protein Size (# AA)Recombinant
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