TOMM20 Antibody - middle region (OASG07248)

Catalog No: OASG07248 (Formerly GWB-7PJDW4)

Size:100 uL

Western Blot using HeLa

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB
• Additional Information: Function: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.
  Cellular Localization: Mitochondrion outer membrane
• Reconstitution and Storage: Store at -20 C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived between 30-110 amino acids from the Internal region of human Tom20.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
• Specificity: Tom20 Polyclonal Antibody detects endogenous levels of Tom20 protein.
• Application Info: WB:1:500-1:2000
  ELISA 1:40000

Target Info

• Gene Symbol: TOMM20
• Gene Full Name: translocase of outer mitochondrial membrane 20 homolog (yeast)
• Alias Symbols: MAS20, MOM19, TOM20
• NCBI Gene Id: 9804
• Description of Target: Tom20 is a protein encoded by the TOMM20 gene which is approximately 16,2 kDa. Tom20 is localised to the mitochondrion outer membrane and is involved in deubiquitination, metabolism of proteins, pink/parkin mediated mitophagy, and glucose / energy metabolism. It is a central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Tom20 is expressed in the nervous system, bone marrow, pancreas, eye and liver. Mutations in the TOMM20 gene result in Perry syndrome and infantile neuroaxonal dystrophy. STJ96061 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Tom20 protein.
• Uniprot ID: Q15388, Q9DCC8, Q62760
• Molecular Weight: 17 kDa