TOB1 Antibody - middle region (ARP52105_P050)

Catalog No: ARP52105_P050

WB Suggested Anti-TOB1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Yeast
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TOB1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 82%; Pig: 93%; Rat: 92%; Yeast: 100%
• Peptide Sequence: Synthetic peptide located within the following region: DLLKQKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKT
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-TOB1 (ARP52105_P050) antibody is Catalog # AAP52105 (Previous Catalog # AAPP42421)

Target Info

• Gene Symbol: TOB1
• Gene Full Name: Transducer of ERBB2, 1
• Alias Symbols: TOB, TROB, APRO5, APRO6, PIG49, TROB1
• NCBI Gene Id: 10140
• Protein Name: Protein Tob1
• Description of Target: This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.
• Uniprot ID: P50616
• Protein Accession #: NP_005740
• Nucleotide Accession #: NM_005749
• Protein Size (# AA): 345
• Molecular Weight: 38kDa
• Protein Interactions: CORO7; APP; DTL; CDC7; PABPC1; CHAF1A; PAN2; UBR5; ELAVL1; SMAD3; CTNNB1; UBC; SKP2; SCMH1; MARCKS; SETDB1; CNOT7; SMAD9; SMAD5; SMAD6; SMAD1; SMAD2; SMAD4; MAPK1; ERBB2; RPS6KA1; MAPK9;