TNRC6A Antibody - N-terminal region : HRP (ARP40956_P050-HRP)

Catalog No: ARP40956_P050-HRP

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Dog, Horse
• Product Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: HRP: Horseradish Peroxidase
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TNRC6A
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 93%; Horse: 100%; Human: 100%; Mouse: 100%
• Peptide Sequence: Synthetic peptide located within the following region: RELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQ
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-TNRC6A (ARP40956_P050-HRP) antibody is Catalog # AAP40956 (Previous Catalog # AAPS02706)
• Reference: Eulalio,A., (2008) Nat. Struct. Mol. Biol. 15 (4), 346-353
• Publications:

  Bukong, T. N., Hou, W., Kodys, K. & Szabo, G. Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells. Hepatology 57, 70-80 (2013). WB, Horse, Mouse, Human, Dog 22898980

Target Info

• Gene Symbol: TNRC6A
• Gene Full Name: Trinucleotide repeat containing 6A
• Alias Symbols: GW1, FAME6, GW182, TNRC6, CAGH26
• NCBI Gene Id: 27327
• Protein Name: Trinucleotide repeat-containing gene 6A protein
• Description of Target: TNRC6A is a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: Q8NDV7
• Protein Accession #: NP_055309
• Nucleotide Accession #: NM_014494
• Protein Size (# AA): 1962
• Molecular Weight: 210kDa
• Protein Interactions: TRIP13; CEP250; TRIM65; AGO3; AGO2; AGO1; UBC; SAV1; AGO4; CUL3; UBR5; PABPC1; WNK1;