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TNRC6A Antibody - N-terminal region (ARP40956_P050)

100 ul
$319.00
In Stock
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Conjugation Options

ARP40956_P050-FITC Conjugated

ARP40956_P050-HRP Conjugated

ARP40956_P050-Biotin Conjugated

Gene Symbol:
TNRC6A
Official Gene Full Name:
Trinucleotide repeat containing 6A
NCBI Gene Id:
27327
Protein Name:
Trinucleotide repeat-containing gene 6A protein
Swissprot Id:
Q8NDV7
Protein Accession #:
NP_055309
Nucleotide Accession #:
NM_014494
Alias Symbols:
CAGH26, DKFZp666E117, FLJ22043, GW1, GW182, KIAA1460, MGC75384, TNRC6
Replacement Item:
This antibody may replace item sc-374458 from Santa Cruz Biotechnology.
Description of Target:
TNRC6A is a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
1962
Molecular Weight:
210kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express TNRC6A.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express TNRC6A.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human TNRC6A
Predicted Species Reactivity:
Dog, Horse, Human, Mouse
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Dog: 93%; Horse: 100%; Human: 100%; Mouse: 100%
Complete computational species homology data:
Anti-TNRC6A (ARP40956_P050)
Peptide Sequence:
Synthetic peptide located within the following region: RELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQ
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
TRIP13; CEP250; TRIM65; AGO3; AGO2; AGO1; UBC; SAV1; AGO4; CUL3; UBR5; PABPC1; WNK1;
Blocking Peptide:
For anti-TNRC6A (ARP40956_P050) antibody is Catalog # AAP40956 (Previous Catalog # AAPS02706)
Datasheets/Manuals:
Printable datasheet for anti-TNRC6A (ARP40956_P050) antibody
Target Reference:
Eulalio,A., (2008) Nat. Struct. Mol. Biol. 15 (4), 346-353
Publications:

Bukong, T. N., Hou, W., Kodys, K. & Szabo, G. Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells. Hepatology 57, 70-80 (2013). WB, Dog, Horse, Human, Mouse 22898980

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