Catalog No: ARP42120_P050
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ARP42120_P050
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Datasheets/ManualsPrintable datasheet for anti-TNNT1 (ARP42120_P050) antibody
Product Info
Tested Species ReactivityHuman, Mouse
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human TNNT1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 85%
Peptide SequenceSynthetic peptide located within the following region: WIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK
Concentration0.5 mg/ml
Blocking PeptideFor anti-TNNT1 (ARP42120_P050) antibody is Catalog # AAP42120 (Previous Catalog # AAPP24505)
Enhanced Validation
WBY
SPR
YCHAROS
ReferenceWitt,S.H., (2005) J. Mol. Biol. 350 (4), 713-722
Gene SymbolTNNT1
Gene Full NameTroponin T type 1 (skeletal, slow)
Alias SymbolsANM, TNT, NEM5, STNT, TNTS
NCBI Gene Id7138
Protein NameTroponin T, slow skeletal muscle
Description of TargetTNNT1 is a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year.This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.
Uniprot IDP13805
Protein Accession #NP_003274
Nucleotide Accession #NM_003283
Protein Size (# AA)278
Molecular Weight33kDa
Protein InteractionsCCDC136; TFIP11; LDOC1; MORF4L1; TBPL1; TPM3; TPM1; TNNT1; NFE2L2; KRT40; UBC; PI4KA; SERPINA4; OSM; MARS; HSP90AB1; FYN; EEF1G; DDX5; CHD3; BLOC1S2; C2orf44; ZNF768; ZNF250; ZC3H15; NAGK; HMP19; TRA2A; TMEM98; ARMC8; OSBP2; ZKSCAN5; LARP1; NACAD; SNW1; S
  1. What is the species homology for "TNNT1 Antibody - middle region (ARP42120_P050)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish".

  2. How long will it take to receive "TNNT1 Antibody - middle region (ARP42120_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "TNNT1 Antibody - middle region (ARP42120_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TNNT1 Antibody - middle region (ARP42120_P050)"?

    This target may also be called "ANM, TNT, NEM5, STNT, TNTS" in publications.

  5. What is the shipping cost for "TNNT1 Antibody - middle region (ARP42120_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TNNT1 Antibody - middle region (ARP42120_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "TNNT1 Antibody - middle region (ARP42120_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "33kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TNNT1 Antibody - middle region (ARP42120_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "TNNT1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "TNNT1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "TNNT1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "TNNT1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "TNNT1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "TNNT1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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