TNKS2 Recombinant Protein (OPCD00345)

Catalog No: OPCD00345

TNKS2 Recombinant Protein (OPCD00345) using SDS-PAGE

TNKS2 Recombinant Protein (OPCD00345) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser959-Gly1166
  Subcellular Location: Nucleus, Cytoplasm, Golgi apparatus
  Isoelectric Point: 8.5
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: TNKS2
• Gene Full Name: tankyrase 2
• Alias Symbols: ADP-ribosyltransferase diphtheria toxin-like 6;ARTD6;PARP-5b;PARP5B;PARP-5c;PARP5C;pART6;poly [ADP-ribose] polymerase 5B;poly [ADP-ribose] polymerase tankyrase-2;protein poly-ADP-ribosyltransferase tankyrase-2;TANK2;tankyrase II;tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2;tankyrase-like protein;tankyrase-related protein;TNKL;TNKS-2;TRF1-interacting ankyrin-related ADP-ribose polymerase 2.
• NCBI Gene Id: 80351
• Protein Name: Tankyrase-2
• Description of Target: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.
• Uniprot ID: Q9H2K2
• Protein Accession #: NP_079511.1
• Nucleotide Accession #: NM_025235.3
• Protein Size (# AA): Ser959~Gly1166
• Molecular Weight: 29kDa